npj Precision OncologyCancer BiologyPeer-reviewed journal article
OnCorr: A pan-cancer mRNA-protein correlation tool for precision oncology
Urwah NawaziD, Niantao DengiD, Ori LivsoniD, Chelsea MayohiD, Loretta M. S. LauiD, Roger R. ReddeliD, Bhavna D. PadhyeiD, Rebecca C. PoulosiD
Abstract
Proteins are ultimately responsible for cellular phenotypes and are targeted by most anticancer drugs. However, beyond immunohistochemistry, proteins are not typically measured in precision oncology, meaning transcriptomics is used as a proxy. To determine how informative mRNA is for guiding personalised treatments, mRNA-protein correlations were analysed in three large pan-cancer datasets and made available in a web portal (https://procan.shinyapps.io/OnCorr/). OnCorr can be integrated into precision medicine programs to augment transcriptomics.
- organism: human
- assay: bulk RNA-seq
- research focus: gene regulatory network inference
- research focus: protein structure prediction
- research focus: drug response / drug discovery
- approach: statistical model
- Citations
- 1
- FWCI
- 2.08
- Field percentile
- top 19%
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