Swathi Ramachandra Upadhya

The paper shows that gene loss in cancer is often compensated by paralog protein abundance changes, stabilizing protein-protein interaction networks and creating therapeutic vulnerabilities.

The paper assesses how antibody reliability affects mRNA-protein correlations in TCGA tumour samples, finding lower correlations with less reliable antibodies.

The paper shows that measurement reproducibility explains much of the variation in mRNA-protein correlation across studies and pathways.