Author

R. Zubarev

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:proteomics· 6 Research Focus:drug response / drug discovery· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Vegvari· 4 shared P. Sabatier· 4 shared M. Gaetani· 3 shared A. A. Saei· 2 shared A. Chernobrovkin· 2 shared C. Beusch· 2 shared C. M. Beusch· 2 shared H. Gharibi· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersImmunology

A. Vegvari

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Do light eaters live shorter lives? The case of ultralight Caenorhabditis elegans

X. Zhang, H. Gharibi, C. M. Beusch, Z. Meng, A. Saei Dibavar, M. Gaetani, R. Zubarev

This study shows that ultralight Caenorhabditis elegans, grown on isotopically depleted bacteria, have shorter lifespans despite faster growth and maturation.

bioRxiv · Feb 13, 2024 · PreprintBiochemistry

Brain endothelial cells exposure to malaria parasites links Type I interferon signalling to antigen presentation, immunoproteasome activation, endothelium disruption and cell metabolic adaptation

A. M. Muktadir Shafi, A. Vegvari, R. Zubarev, C. Penha-Goncalves

This study shows that Type I interferon signaling in brain endothelial cells exposed to malaria parasites enhances antigen presentation and disrupts the endothelial barrier, contributing to cerebral malaria pathology.

bioRxiv · Nov 26, 2022Immunology

System-wide profiling by proteome integral solubility alteration assay of drug residence times for target characterization

P. Sabatier, C. M. Beusch, Z. Meng, R. Zubarev

This paper introduces a method to measure drug residence times on targets by analyzing protein solubility changes after drug removal, enabling better target characterization for drug development.

bioRxiv · Jun 27, 2022Biochemistry

Abnormal (hydroxy)prolines deuterium content redefines hydrogen chemical mass

H. Gharibi, A. L. Chernobrovkin, G. Eriksson, A. S. Dibavar, Z. Timmons, A. C. Kitchener, D. Kalthoff, K. Liden, A. A. Makarov, R. Zubarev

The paper finds unexpectedly high deuterium levels in proline and hydroxyproline residues of seal bone collagen, challenging assumptions about diet and environmental influences on isotopic signatures.

bioRxiv · Nov 11, 2021Biochemistry

Single Cell Chemical Proteomics (SCCP) Interrogates the Timing and Heterogeneity of Cancer Cell Commitment to Death

A. Vegvari, J. E. Rodriguez, R. Zubarev

This study applies single cell chemical proteomics to analyze the time-dependent and heterogeneous response of cancer cells to anticancer drugs.

bioRxiv · Apr 21, 2021Cancer Biology

A spindle and thread-mechanism unblocks translation of N-terminally disordered proteins

M. Kaldmae, T. Vosselman, X. Zhong, D. Lama, G. Chen, M. Saluri, N. Kronqvist, J. W. Siau, A. S. Ng, F. J. Ghadessy, P. Sabatier, B. Vojtesek, M. Sarr, C. Sahin, N. Osterlund, , M. Landreh

This study shows that fusing disordered proteins to an engineered spider silk domain improves their translation efficiency and activity in cells.

bioRxiv · Feb 22, 2021 · PreprintBiochemistry

System-wide Identification and prioritization of Enzyme Substrates by Thermal Analysis (SIESTA)

A. A. Saei, C. Beusch, P. Sabatier, J. Astorga Wells, A. Chernobrovkin, S. Rodin, K. Nareoja, A.-G. Thorsell, T. Karlberg, Q. Cheng, S. L. Lundstrom, M. Gaetani, A. Vegvari, E. S. J. Arner, H. Schuler, R. Zubarev

SIESTA identifies and prioritizes enzyme substrates by detecting thermal stability changes caused by post-translational modifications, demonstrating effectiveness across multiple enzyme systems.

bioRxiv · Jan 21, 2020Biochemistry

ProTargetMiner: A proteome signature library of anticancer molecules for functional discovery

A. A. Saei, A. Chernobrovkin, P. Sabatier, B. Zhang, C. Beusch, U. Guler Tokat, M. Gaetani, A. Vegvari, R. Zubarev

ProTargetMiner provides a proteome signature library of anticancer molecules in A549 cells, revealing drug targets, co-regulation networks, and essential proteins for cellular functions.

bioRxiv · Sep 18, 2018Cell Biology