ZIKA - How Fast Does This Virus Mutate ?

Abstract

The World Health Organisation has declared the present epidemic of infection with the Zika virus to be a Public Health Emergency of International Concern. The virus appears to have spread from Thailand to French Polynesia in 2013, and has since infected over a million people in the countries of South and Central America. In most cases the infection is mild and transient, but the virus does appear to be strongly neurotropic and the presumptive cause of both birth defects in foetuses and Guillain-Barre syndrome in some adults.\n\nIn this paper the techniques and utilities developed in the study of mitochondrial DNA are applied to the Zika virus. As a result it is possible to show in a simple manner how a phylogenetic tree may be constructed and how the mutation rate of the virus can be measured.\n\nThe study shows the mutation rate to vary between 12 and 25 bases a year, in a viral genome of 10,272 bases. This rapid mutation rate will enable the geographic spread of the epidemic to be monitored easily and may also prove useful in assisting the identification of preventative measures that are working, and those which are not.