C. Shan

Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants

This paper evaluates RQ3013, an mRNA vaccine against SARS-CoV-2 variants, showing robust immune responses and protection in animal models.

Anthracyclines inhibit SARS-CoV-2 infection

This study identifies anthracyclines as potential SARS-CoV-2 inhibitors through a microbial metabolite screening effort, showing they inhibit viral infection via different mechanisms.

Visualization of mitochondrial cristae and mtDNA evolvement and interactions with super-resolution microscopy

This study uses super-resolution microscopy to visualize mitochondrial cristae and mtDNA interactions, revealing their dynamic relationship and distribution patterns under different cellular conditions.

Transcriptome analysis of protein kinase MoCK2 affect acetyl-CoA metabolism and import of CK2 interacting mitochondrial proteins into mitochondria in rice blast fungus Magnaporthe oryzae

This paper investigates the role of MoCK2 in rice blast fungus metabolism and mitochondrial protein import, finding it affects acetyl-CoA production and mitochondrial function essential for pathogenesis.

Fast, live-cell imaging of 15 intracellular compartments by deep learning segmentation of super-resolution data

This paper uses deep learning to segment 15 intracellular compartments from super-resolution images with one dye, achieving high accuracy and faster imaging.

Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques

This study shows a single-dose AAV-based vaccine induces long-lasting neutralizing antibodies against multiple SARS-CoV-2 variants in rhesus macaques.

A human antibody with blocking activity to RBD proteins of multiple SARS-CoV-2 variants including B.1.351 showed potent prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus macaques

Emergence of Zika virus: Direct reversion of mutations and fitness restoration prior to spread to the Americas

This study identifies four mutations in Zika virus that reversed prior mutations, restoring fitness for urban transmission and increasing epidemic risk before the virus spread to the Americas.

Enhancing generating and collecting efficiency of single particle upconverting luminescence at low-level power excitation

This study improves the luminescence efficiency of upconverting nanoparticles at low excitation power by optimizing dopant concentrations and adding a core-shell structure.

Mitochondrial dynamics quantitatively revealed by STED nanoscopy with an enhanced squaraine variant probe

This study uses STED nanoscopy with a new dye to visualize mitochondrial cristae dynamics in live cells at high resolution.

Fast, Accurate Polarization and Polarity Imaging withPolarized Structured Illumination

This paper introduces a method for fast and accurate polarization and polarity imaging using polarized structured illumination, improving measurement accuracy and speed compared to conventional techniques.