Hayden C. Metsky

This study identifies distinct E. coli transcriptional profiles in the guts of recurrent UTI sufferers using a novel pangenome hybrid selection method.

This paper designs artificial CRISPR-Cas13a guide RNAs using model-directed algorithms, showing improved sensitivity and variant discrimination in nucleic acid detection.

This paper designs viral diagnostics using a model-based optimization approach, achieving higher sensitivity and specificity across viral genomic variation.

This paper develops CRISPR-Cas13a-based diagnostics for real-time detection of Ebola and Lassa viruses in field settings, demonstrating sensitivity and usability in clinical samples.

A machine-learning design pipeline produced CRISPR-Cas13 detection assays for 67 viral taxa; the best of 4 screened SARS-CoV-2 designs reached 10 copies/μl on synthetic RNA.

The paper analyzes mumps virus circulation in the US using genomic data to show multiple co-circulating lineages and transmission patterns, but finds no evidence of vaccine escape variants.

The paper introduces CATCH, a method for designing compact and scalable probe sets to enhance metagenomic sequencing sensitivity, demonstrating improved viral genome recovery and diversity preservation.

This study sequenced 110 Zika virus genomes from 10 countries, revealing rapid expansion in Brazil, multiple introductions into other regions, and undetected circulation before confirmed cases.