Gold Nanocages with a Long SPR Peak Wavelength as Contrast Agents for Optical Coherence Tomography Imaging at 1060 nm

There has been growing interest in optical coherence tomography (OCT) imaging at a wavelength of 1060 nm. However, potential contrast agents for OCT imaging at this specific wavelength has not been thoroughly investigated. In this study, we present the synthesis and optical characterization of gold nanocages with a small edge length ([~]65 nm) and a surface plasmon resonance peak around 1060 nm. These nanocages represent a class of potential contrast agents for OCT at 1060 nm. OCT imaging experiments were conducted on phantoms and in vivo mouse tissues using a 1060-nm swept-source OCT system, demonstrating significant enhancement in imaging contrast due to the presence of the gold nanocages. GRAPHICAL ABSTRACTGold nanocages with a long SPR peak wavelength as OCT imaging contrast agents at 1060 nm O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=105 SRC="FIGDIR/small/642209v1_ufig1.gif" ALT="Figure 1"> View larger version (36K): org.highwire.dtl.DTLVardef@179a727org.highwire.dtl.DTLVardef@1cd1e4eorg.highwire.dtl.DTLVardef@180ce47org.highwire.dtl.DTLVardef@166a779_HPS_FORMAT_FIGEXP M_FIG C_FIG