Prevalence of uncoupling protein one genetic polymorphisms and their relationship with cardiovascular and metabolic health

Petros C. Dinas; Eleni Nintou; Maria Vliora; Paraskevi Sakellariou; Anna E. Pravednikova; Agata Witkowicz; Zaur M. Kachaev; Victor V. Kerchev; Ларина Светлана Николаевна; James M. Cotton; Anna Kowalska; Paraskevi Gkiata; Αlexandra Bargiota; Zaruhi Khachatryan; Anahit Hovhannisyan; Mariya Antonosyan; Sona Margaryan; Anna Partyka; Paweł Bogdański; Monika Szulińska; Matylda Kręgielska-Narożna; Rafał Czepczyński; Marek Ruchała; Anna Tomkiewicz; Levon Yepiskoposyan; Lidia Karabon; Yulii V. Shidlovskii; George S. Metsios; Andreas D. Flouris

doi:10.1371/journal.pone.0266386

Genetic & Genomic MedicinePLoS ONEApr 28, 2022

Peer-reviewed journal article

Prevalence of uncoupling protein one genetic polymorphisms and their relationship with cardiovascular and metabolic health

Petros C. Dinas iD, Eleni Nintou iD, Maria Vliora iD, Paraskevi Sakellariou, Anna E. Pravednikova iD, Agata Witkowicz iD, Zaur M. Kachaev iD, Victor V. Kerchev iD, Ларина Светлана Николаевна iD, James M. Cotton iD, Anna Kowalska iD, Paraskevi Gkiata iD, Αlexandra Bargiota iD, Zaruhi Khachatryan iD, Anahit Hovhannisyan iD, Mariya Antonosyan iD, Sona Margaryan, Anna Partyka iD, Paweł Bogdański iD, Monika Szulińska iD, Matylda Kręgielska-Narożna iD, Rafał Czepczyński iD, Marek Ruchała iD, Anna Tomkiewicz iD, Levon Yepiskoposyan iD, , Andreas D. Flouris iD

Abstract

The contribution of UCP1 single nucleotide polymorphisms (SNPs) to susceptibility for cardiometabolic pathologies (CMP) and their involvement in specific risk factors for these conditions varies across populations. We tested whether UCP1 SNPs A-3826G, A-1766G, Ala64Thr and A-112C are associated with the most common CMP (cardiovascular disease, hypertension, metabolic syndrome, and type-2 diabetes) and CMP risk factors. This case-control study included blood sample collection from 2,283 Caucasians (1,139 healthy; 1,144 CMP) across Armenia, Greece, Poland, Russia and United Kingdom for genotyping of the above-mentioned SNPs. We extended the results via a systematic review and meta-analysis, covering PubMed, Embase, and Cochrane Library databases. In Armenia the GA genotype and A allele of Ala64Thr were associated with [~]2-fold higher risk for CMP compared to the GG genotype or G allele, respectively (p0.05). Thus, we conclude that the studied SNPs could be associated with the most common CMP and their risk factors in some populations.

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