Saskia P. Hagenaars

The paper investigates gene-environment interactions for depressive symptoms using UK Biobank data, finding limited polygenic-environment interactions but significant residual-environment interactions.

Meta-analysis of 41,917 European-ancestry bipolar disorder cases versus 371,549 controls yields 64 risk loci (33 novel), neuronal and synaptic gene enrichment, and 15 eQTL-prioritized genes.

This study evaluates polygenic scoring methods in a reference-standardized framework, finding that LDPred2, lassosum, and PRScs provide the best predictive performance.

This study evaluates gene expression risk scores (GeRS) for predicting neuropsychiatric and anthropometric traits, finding they improve prediction when combined with polygenic risk scores (PRS).

This study finds that depression with atypical neurovegetative symptoms has distinct genetic links to immune-metabolic traits and alcohol consumption.

This study uses polygenic risk scores for major depression to examine the continuous nature of depressive symptoms across a large UK Biobank sample.

This study examines the genomic architecture of neuroanatomical diversity using SNP data and MRI, finding polygenic influences and environmental factors affecting brain asymmetry.

The paper examines phenotypic and genetic relationships between cannabis use, depression, and self-harm using UK Biobank and consortium data, finding associations and genetic correlations.

The paper identifies a genetic subgroup within depression linked to age of natural menopause using UK Biobank data, but finds no replication in other cohorts.

This study investigates genetic associations between major depression and cardio-metabolic traits, finding shared genetic aetiology regardless of depression onset age.

This study uses polygenic scores to predict cognitive ability at age 70 and cognitive change from 70 to 79, finding limited predictive validity compared to APOE e4.

A meta-analysis of 807,553 people from 23andMe, UK Biobank and PGC finds 102 depression variants. 87 of them replicate in 1,306,354 individuals, and heritability is enriched in prefrontal brain regions.

This study examines the association between polygenic risk scores for neurodegenerative disorders and cognitive performance, finding lower cognitive performance with higher risk scores for AD, ALS, and FTD.

This study identifies 99 genetic loci associated with general cognitive function using data from 280,360 individuals, finding genes linked to brain structure and neurodegenerative disorders.

This study identifies six new Alzheimer's disease-associated loci using GWAS on family history data from UK Biobank and consortium data, with potential implications for precision medicine.

This study conducts a GWAS on depression phenotypes in UK Biobank, identifying genetic variants enriched in excitatory synaptic pathways.

This study uses MTAG to combine GWAS of education and income with a GWAS of intelligence, identifying 107 loci and 233 genes associated with intelligence.

This study performs genome-wide meta-analyses of depression in two large cohorts, finding one significant locus and suggesting larger sample sizes may be more informative than phenotypic stratification.

The paper identifies 116 independent genetic variants associated with neuroticism in over 329,000 UK Biobank participants and finds genetic correlations with mental health traits.

This study examines the genetic architecture of trail making test performance and its genetic correlations with cognitive functions in UK Biobank participants.

The paper identifies 25 genetic loci associated with subcortical brain structure volumes in over 40,000 individuals, revealing novel biology and potential drug targets.

This study uses Mendelian randomization to examine causal relationships between cognitive ability, educational attainment, and physical health traits, finding no evidence of causation from health to cognitive ability or from educational attainment to health.

This study examines the genetic overlap between major psychiatric disorders and brain structure in UK Biobank data but finds no significant associations.