Deep brain cancer metastasis detection with wide-volume Raman spectroscopy through a single tapered fiber
Filippo PisanoiD, Mariam Masmudi‐MartíniD, Maria Samuela AndrianiiD, Elena CidiD, Mohammadrahim KazemzadehiD, Marco PisanelloiD, Antonio BalenaiD, Liam CollardiD, Teresa Jurado-Parras, Marco BiancoiD, Patricia Baena, Francesco TantussiiD, Marco Grande, Leonardo Sileo, Francesco GentileiD, Francesco De AngelisiD, Massimo De VittorioiD, Liset Menéndez de la PridaiD, Manuel ValienteiD, Ferruccio PisanelloiD
Abstract
We propose a low-invasive method to enable implantable, large volume Raman spectroscopy in arbitrarily deep brain regions of the mouse brain. Using a single tapered fiber as thin as 1 m at the tip, we identified diagnostic markers of brain metastasis - the most frequent brain tumor in human adults - with overall accuracy [≥] 90%. We view our approach as a promising complement to the existing palette of tools for optical interrogation of the brain.
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