Assessment of SLC25A46 variants in Parkinson's disease

The SLC25A46 gene was recently reported to be associated with Parkinsons disease (PD). Here, we comprehensively investigated the role of SLC25A46 variants in PD patients of European ancestry and assessed susceptibility using whole-genome sequencing data from 1647 patients with PD and 1050 healthy controls. Burden analysis of rare non-synonymous variants across case-control individuals from whole-genome data did not find evidence of SLC25A46 association with PD. Therefore, our results do not support a major role for SLC25A46 in PD in the European population and large-scale sequencing studies of family trios are necessary to further evaluate the role of SLC25A46 in PD etiology.