bioRxivCancer Biology
Mapping chromatin remodelling in glioblastoma identifies epigenetic regulation of key molecular pathways and novel druggable targets.
C. Vinel, J. Boot, W. Jin, N. Pomella, C. Mein, R. Zabet, S. Marino
Abstract
Analysis of chromatin remodelling in neoplastic stem cells as compared to ontogenetically related neural stem cells, reveals multifactorial epigenetic regulation of signalling pathways known to contribute to glioblastoma development. It also identifies novel epigenetically regulated druggable target genes on a patient-specific level, including SMOX and GABBR2 which could be further developed for future translational approaches to more effectively treat this neoplasm.
- organism: human
- assay: ChIP-seq
- research focus: chromatin & epigenetic regulation
- approach: experimental assay
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- macroH2A2 shapes chromatin accessibility at enhancer elements in glioblastoma to modulate a targetable self-renewal epigenetic network
A. Nikolic, A. Bobyn, … M. Gallo·bioRxiv·Feb 23, 2021
- WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma
K. Mitchell, S. Shakya, … J. D. Lathia·bioRxiv·Sep 20, 2021
- Mapping chromatin accessibility and active regulatory elements reveals new pathological mechanisms in human gliomas
K. Stepniak, M. A. Machnicka, … B. Wilczynski·bioRxiv·Mar 20, 2020
- Suppression of YAP/TAZ molecular targets by epigenetic editing interferes with GBM growth and invasiveness
Eva Baronchelli, Silvia Ferretti, … Alessandro Sessa·bioRxiv·Mar 15, 2026
- EZH2 inhibition in glioblastoma stem cells increases the expression of neuronal genes and the neuronal developmental regulators ZIC2, ZNF423 and MAFB
B. Kader, R. DiStefano, … A. G. West·bioRxiv·Nov 22, 2021
- Leveraging epigenetic vulnerabilities of the stem cell-related HOX-signature in glioblastoma
Davide Chiesi, Pierre Bady, … Monika E. Hegi·bioRxiv·May 29, 2026