Author

S. Shakya

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Microbiology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. G. Hubert· 2 shared L. Wallace· 2 shared A. Gromovsky· 1 shared A. Kashyap· 1 shared A. Knudsen· 1 shared A. Lauko· 1 shared A. N. Sharma· 1 shared A. P. Patel· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

C. G. Hubert

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Prolonged in-vivo tracking of vitreous fluid and its early diagnostic imaging biomarkers for cancer growth

M. Goswami, S. Shakya, P. Zhang

This study tracks vitreous fluid cells in glioblastoma xenografts using OCT imaging and finds a correlation between cell density and tumor growth, suggesting vitreous cell density as an early diagnostic biomarker.

bioRxiv · Feb 15, 2023 · PreprintCancer Biology

Novel strains of Campylobacter cause diarrheal outbreak in Rhesus macaques (Macaca mulatta) of Kathmandu Valley

R. Napit, P. Manandhar, A. Poudel, P. G. Rajbhandari, S. Watson, S. Shakya, S. M. Pradhan, A. N. Sharma, C. K. Johnson, J. K. Mazet, D. Karmacharya

This study identifies Campylobacter spp. as a cause of a 2018 diarrhea outbreak in Rhesus macaques in Kathmandu Valley, detecting novel strains and linking them to human and animal infections.

bioRxiv · Jun 20, 2022Microbiology

WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma

K. Mitchell, S. Shakya, S. Arora, S. A. Sprowls, D. J. Silver, C. M. Goins, L. Wallace, G. Roversi, R. Schafer, K. Kay, T. E. Miller, A. Lauko, A. Kashyap, J. D. Kass, E. E. Mulkearns-Hubert, , J. D. Lathia

This study identifies WDR5 as an essential epigenetic regulator in therapy-resistant glioblastoma cancer stem cells and shows that WDR5 inhibitors disrupt CSC maintenance and tumor growth.

bioRxiv · Sep 20, 2021Cancer Biology

Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches

S. Shakya, A. Gromovsky, J. Hale, A. Knudsen, B. Prager, L. Wallace, L. O. Penalva, P. Ivanova, H. A. Brown, B. Kristensen, J. Rich, J. Lathia, J. M. Brown, C. G. Hubert

This study identifies distinct lipid metabolism patterns in glioblastoma stem and non-stem cells across different tumor microenvironments, highlighting potential therapeutic targets.

bioRxiv · Sep 20, 2020Cancer Biology

Cutaneous Wounds in Mice Lacking Tumor Necrosis Factor-stimulated Gene-6 Exhibit Delayed Closure and an Abnormal Inflammatory Response

S. Shakya, J. A. Mack, M. Alipour, E. V. Maytin

This study shows that TSG-6 deficiency in mice leads to delayed wound closure and abnormal inflammation, with TSG-6 reintroduction rescuing these defects.

bioRxiv · Apr 9, 2020Physiology

Genome-wide increased copy number is associated with emergence of super-fit clones of the Irish potato famine pathogen Phytophthora infestans

B. Knaus, J. Tabima, S. Shakya, H. Judelson, N. Grunwald

The paper analyzes genomic data to show that modern clonal lineages of Phytophthora infestans have increased copy number compared to sexual populations at the center of origin.

bioRxiv · May 16, 2019Microbiology