Author

J. D. Lathia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 14 Immunology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 15 Organism:human· 14 Research Focus:cancer & tumor microenvironment· 12 Research Focus:cell type annotation· 8 Assay:proteomics· 6 Assay:bulk RNA-seq· 5 Organism:mouse· 4 Research Focus:differential expression· 3

Frequent Co-Authors

D. J. Silver· 10 shared D. Bayik· 7 shared A. Lauko· 5 shared J. M. Brown· 4 shared J. S. Hale· 4 shared C. K. A. Neumann· 3 shared D. C. Watson· 3 shared E. E. Mulkearns-Hubert· 3 shared

Activity by Year

2017-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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10 shared papersCancer Biology

D. J. Silver

Mutual co-authors in cluster

Author profile →

17 papers

Recent·Most cited

Sex-specific T cell exhaustion drives differential immune responses in glioblastoma

J. Lee, M. Nicosia, D. J. Silver, C. Li, D. Bayik, D. C. Watson, A. Lauko, S. Johnson, M. McGraw, M. Grabowski, D. Kish, A. Desai, W. Goodman, S. Cameron, H. Okada, , J. D. Lathia

This study shows male T cells are more exhausted in glioblastoma, leading to worse outcomes and better response to anti-PD1 treatment compared to females.

bioRxiv · Aug 17, 2022 · PreprintImmunology

Sex-specific niche signaling contributes to sexual dimorphism following stem cell transplantation

J. N. P. Smith, B. A. Cordova, B. Richardson, K. F. Christo, J. Campanelli, A. V. Broncano, J. Chen, J. Lee, S. J. Cameron, J. D. Lathia, W. A. Goodman, M. J. Cameron, A. B. Desai

This paper identifies sex-specific niche signaling differences in hematopoietic regeneration following stem cell transplantation and shows exogenous sex hormones regulate hematopoietic stem and progenitor cells.

bioRxiv · Jun 13, 2022 · PreprintImmunology

SerpinB3 drives cancer stem cell survival in glioblastoma

A. Lauko, J. Volovetz, S. M. Turaga, D. Bayik, D. C. Watson, D. J. Silver, K. Mitchell, E. Mulkearns-Hubert, K. Desai, M. Midha, J. Hao, K. McCortney, A. Steffens, U. Naik, M. S. Ahluwalia, , J. D. Lathia

This study identifies SerpinB3 as a key driver of glioblastoma cancer stem cell survival and shows that targeting it enhances radiation therapy efficacy in pre-clinical models.

bioRxiv · Dec 21, 2021Cancer Biology

WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma

K. Mitchell, S. Shakya, S. Arora, S. A. Sprowls, D. J. Silver, C. M. Goins, L. Wallace, G. Roversi, R. Schafer, K. Kay, T. E. Miller, A. Lauko, A. Kashyap, J. D. Kass, E. E. Mulkearns-Hubert, , J. D. Lathia

This study identifies WDR5 as an essential epigenetic regulator in therapy-resistant glioblastoma cancer stem cells and shows that WDR5 inhibitors disrupt CSC maintenance and tumor growth.

bioRxiv · Sep 20, 2021Cancer Biology

Horizontal mitochondrial transfer from the microenvironment increases glioblastoma tumorigenicity

D. C. Watson, D. Bayik, S. E. Williford, A. Lauko, Y. Zhou, G. Deshpande, J. Seder, J. A. Mears, F. Cheng, A. B. Hjelmeland, J. D. Lathia

The paper identifies horizontal mitochondrial transfer from astrocytes to glioblastoma cells as a mechanism that enhances tumorigenicity by improving mitochondrial function and metabolic capacity.

bioRxiv · Sep 1, 2021Cancer Biology

HAUSP Stabilizes SOX2 through Deubiquitination to Maintain Self-renewal and Tumorigenic Potential of Glioma Stem Cells

Z. Huang, K. Zhai, Q. Wu, X. Fang, Q. Huang, W. Tao, J. D. Lathia, J. S. Yu, J. N. Rich, S. Bao

This study identifies HAUSP as a deubiquitinase that stabilizes SOX2 in glioma stem cells, maintaining their self-renewal and tumorigenic potential, and shows that targeting HAUSP can enhance GBM treatment.

bioRxiv · Jun 9, 2021 · PreprintCancer Biology

Preclinical modeling of surgery and steroid therapy for glioblastoma reveals changes in immunophenotype that are associated with tumor growth and outcome

B. Otvos, T. J. Alban, M. M. Grabowski, D. Bayik, E. E. Mulkearns-Hubert, T. Radivoyevitch, a. Rabljenovic, S. Johnson, C. Androjna, A. M. Mohammadi, G. Barnett, M. S. Ahluwalia, M. A. Vogelbaum, P. E. Fecci, J. D. Lathia

The paper develops a mouse model to study how surgery and steroids affect immune responses in glioblastoma, finding systemic lymphocyte reduction and correlations with tumor growth and patient outcomes.

bioRxiv · Aug 12, 2020Cancer Biology

Cancer Stem Cell Enrichment and Metabolic Substrate Adaptability are Driven by Hydrogen Sulfide Suppression in Glioblastoma

D. J. Silver, G. A. Roversi, N. Bithi, C. K. A. Neumann, K. M. Troike, G. K. Ahuja, O. Reizes, J. M. Brown, C. Hine, J. D. Lathia

A high-fat diet accelerates glioblastoma by inhibiting hydrogen sulfide production, leading to cancer stem cell enrichment and reduced treatment response.

bioRxiv · Mar 8, 2020 · PreprintCancer Biology

Membrane-Bound O-Acyltransferase 7 (MBOAT7) is a Key Regulator of Glycolysis in Clear Cell Renal Carcinoma.

C. K. A. Neumann, W. Massey, D. Orabi, R. Zhang, D. J. Silver, J. D. Lathia, J. M. Brown

This study shows MBOAT7 regulates glycolysis in ccRCC by reducing glycolytic gene expression, intermediates, and respiration, and improving survival in xenograft models.

bioRxiv · Feb 10, 2020 · PreprintCancer Biology

Cholangiocarcinoma presents a distinct myeloid-derived suppressor cell signature compared to other hepatobiliary cancers

D. Bayik, A. Lauko, G. A. Roversi, E. Serbinowski, L.-A. Acevedo-Moreno, C. Lanigan, M. Orujov, A. Lo, T. Alban, D. J. Silver, J. M. Brown, D. S. Allende, F. N. Aucejo, J. D. Lathia

The paper identifies a distinct myeloid-derived suppressor cell (MDSC) signature in cholangiocarcinoma (CCA) compared to other hepatobiliary cancers, linking MDSC levels to disease outcomes and potential therapeutic targets.

bioRxiv · Dec 11, 2019 · PreprintPathology

MBOAT7-Driven Phosphatidylinositol Remodeling Promotes the Progression of Clear Cell Renal Cell Carcinoma.

C. K. A. Neumann, R. Zhang, D. J. Silver, V. Venkaleshwari, C. A. Traughber, C. Przybycin, D. Bayik, J. D. Smith, J. D. Lathia, B. I. Rini, J. M. Brown

This study identifies MBOAT7-driven phosphatidylinositol remodeling as a driver of clear cell renal cell carcinoma progression and highlights MBOAT7 as a potential therapeutic target.

bioRxiv · May 23, 2019Cancer Biology

Asymmetric Division Promotes Therapeutic Resistance In Glioblastoma Stem Cells

M. Hitomi, A. P. Chumakova, D. J. Silver, A. M. Knudsen, W. D. Pontius, S. Murphy, N. Anand, B. W. Kristensen, J. D. Lathia

The paper shows that asymmetric division in glioblastoma stem cells generates daughter cells with enhanced therapeutic resistance and co-inherited growth factor receptors.

bioRxiv · Mar 6, 2019Cancer Biology

ADAMDEC1 maintains a novel growth factor signaling loop in cancer stem cells

J. S. Hale, A. Jimenez-Pascual, A. Kordowski, J. Pugh, S. Rao, D. J. Silver, T. Alban, D. B. Watson, R. Chen, T. M. McIntyre, G. Colombo, G. Taraboletti, K. O. Holmberg, K. Forsberg-Nilsson, J. D. Lathia, F. Siebzehnrubl

This study identifies a novel signaling loop involving ADAMDEC1 and FGF2/FGFR1 that maintains glioblastoma cancer stem cells and shows targeting this loop reduces tumor growth.

bioRxiv · Jan 26, 2019Cancer Biology

Global immune fingerprinting in glioblastoma reveals immune-suppression signatures associated with prognosis

T. J. Alban, A. G. Alvarado, M. D. Sorensen, D. Bayik, J. Volovetz, E. Serbinowski, E. Mulkearns-Hubert, M. Sinyuk, J. S. Hale, G. R. Onzi, M. McGraw, P. Huang, M. M. Grabowski, C. A. Wathen, T. Radivoyevitch, , J. D. Lathia

The paper identifies immune-suppression signatures in glioblastoma (GBM) patients, showing elevated myeloid-derived suppressor cells (MDSCs) linked to poor prognosis and reduced survival.

JCI Insight · Nov 2, 2018Peer-reviewedCancer Biology

High-throughput Automated Single Cell Imaging Analysis Reveals Dynamics Of Glioblastoma Stem Cell Population During State Transition

A. P. Chumakova, M. Hitomi, E. P. Sulman, J. D. Lathia

The paper develops HASCIA, a high-throughput automated single-cell imaging analysis tool, to quantify protein expression and study dynamics of glioblastoma stem cell state transitions.

bioRxiv · Jul 31, 2018Cancer Biology

Development of a Cx46 targeting strategy for cancer stem cells

E. E. Mulkearns-Hubert, L. A. Torre-Healy, D. J. Silver, J. T. Eurich, E. Serbinowski, M. Hitomi, J. Zhou, B. Przychodzen, R. Zhang, S. A. Sprowls, J. S. Hale, T. Alban, A. Berezovsky, B. A. Bell, P. R. Lockman, , J. D. Lathia

This study identifies clofazimine as a Cx46 inhibitor that targets glioblastoma cancer stem cells by disrupting gap junction communication, enhancing the efficacy of temozolomide.

bioRxiv · Mar 26, 2018Cancer Biology

CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors

C. Saygin, A. Wiechert, V. S. Rao, R. Alluru, E. Connor, P. S. Thiagarajan, J. S. Hale, Y. Li, A. Chumakova, A. Jarrar, Y. Parker, D. J. Lindner, A. B. Nagaraj, J. J. Kim, A. DiFeo, , O. Reizes

This study identifies CD55 as a signaling hub that regulates self-renewal and cisplatin resistance in endometrioid tumors through distinct signaling pathways.

bioRxiv · Jun 27, 2017Cancer Biology