Endometrial microbiome in mares with and without clinical endometritis

Abstract

Chronic endometritis (CE) has been recognized as an important disease in the clinical theriogenology practice. Studies have suggested that CE is one of the major causes of infertility in breeding mares. However, a comprehensive analysis of the CE microbiome is currently insufficient in published reports. In this paper, we compared the uterine microbiomes of mares with CE to those of healthy mares and propose that there are significant differences in the composition of the uterine microbiome between these two groups of mares. This study suggests that changes in the uterine microbiome may play a vital role in the development and progression of CE in mares, adds to the understanding of the role of the uterine microbiome in CE and in developing targeted treatment strategies.