Deconvoluted methylation profiles discriminate between closely related melanocytic nevi

Daniel Aldea; Nicolas Macagno; Elise Maréchal; Mathias Moreno; Pauline Romanet; Morgane Pertuit; Jérémy Garcia; N. Dégardin; S. Mallet; Isabelle James; Guillaume Captier; Anne Barlier; Heather Etchevers

doi:10.1016/j.jid.2024.10.595

Cancer BiologyJournal of Investigative DermatologyNov 9, 2024

Peer-reviewed journal article

Deconvoluted methylation profiles discriminate between closely related melanocytic nevi

Daniel Aldea iD, Nicolas Macagno iD, Elise Maréchal iD, Mathias Moreno iD, Pauline Romanet iD, Morgane Pertuit iD, Jérémy Garcia iD, N. Dégardin iD, S. Mallet iD, Isabelle James iD, Guillaume Captier iD, Anne Barlier iD, Heather Etchevers iD

Abstract

Congenital melanocytic nevi (CMN) and common acquired melanocytic nevi (AMN) are melanoma-predisposing skin conditions presenting excessive numbers of melanocytes but arising at different times in life. Appropriately weighted whole-genome methylation analysis can be used as a basis for further research in dermatopathology and as applied here provides new insights into nevus biology.

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