Heather Etchevers

This study identifies RIPOR2 as a downstream target of the RAS/ERK pathway that promotes multinucleation in melanoma cells, contributing to aneuploidy and tumor progression.

This study maps spatially resolved molecular states in congenital melanocytic nevi and associated tumors, revealing distinct melanocyte subpopulations and signaling networks linked to disease progression.

The paper refines a human heart atlas using multi-modal data from the first trimester, identifying novel cell types and spatial features in cardiac development.

This study uses CRISPR/Cas9-edited human pituitary organoids to show that NFKB2 mutations impair corticotroph differentiation, confirming its role in ACTHD.

The paper uses weighted whole-genome methylation analysis to distinguish between congenital and acquired melanocytic nevi.

This study shows that oncogenic MAPK pathway activation in Schwann cells causes congenital and progressive neuropathy in mice, linking RASopathy mutations to peripheral nerve dysfunction.

This study investigates how somatic Pik3ca mutations in neural crest and related lineages cause congenital malformations and vascular anomalies in mice, with implications for human PIK3CA-related disorders.

The paper shows sustained ERK1/2 activation in chicken embryos induces neoplasia in the spinal cord, mimicking early ERK-mediated tumorigenesis.

This paper uses interspecies chimeras to trace the lineage of pericytes and shows they originate from multiple mesenchymal progenitor pools in vertebrate embryos.

This study shows that ectopic Hoxb1 expression in neural crest cells causes craniofacial and cardiac malformations, highlighting its role in development.

The paper shows MC1R is widely expressed in non-cutaneous tissues during embryonic development across chick, mouse, and human, with potential pleiotropic effects on birthweight.