Nicolas Macagno

RIPOR2 promotes multinucleation of melanoma cells downstream of the RAS/ERK oncogenic pathway

This study identifies RIPOR2 as a downstream target of the RAS/ERK pathway that promotes multinucleation in melanoma cells, contributing to aneuploidy and tumor progression.

Spatially resolved diversity in molecular states underlies congenital melanocytic nevi and associated tumors

This study maps spatially resolved molecular states in congenital melanocytic nevi and associated tumors, revealing distinct melanocyte subpopulations and signaling networks linked to disease progression.

Deconvoluted methylation profiles discriminate between closely related melanocytic nevi

The paper uses weighted whole-genome methylation analysis to distinguish between congenital and acquired melanocytic nevi.

Multiple congenital malformations arise from somatic mosaicism for constitutively active Pik3ca signalling

This study investigates how somatic Pik3ca mutations in neural crest and related lineages cause congenital malformations and vascular anomalies in mice, with implications for human PIK3CA-related disorders.