Mathias Moreno

Spatially resolved diversity in molecular states underlies congenital melanocytic nevi and associated tumors

This study maps spatially resolved molecular states in congenital melanocytic nevi and associated tumors, revealing distinct melanocyte subpopulations and signaling networks linked to disease progression.

Multi-modal refinement of the human heart atlas during the first gestational trimester

The paper refines a human heart atlas using multi-modal data from the first trimester, identifying novel cell types and spatial features in cardiac development.

Deconvoluted methylation profiles discriminate between closely related melanocytic nevi

The paper uses weighted whole-genome methylation analysis to distinguish between congenital and acquired melanocytic nevi.

Oncogenic MAPK pathway activation disrupts Schwann cell fate commitment, inducing congenital and progressive neuropathy in mice

This study shows that oncogenic MAPK pathway activation in Schwann cells causes congenital and progressive neuropathy in mice, linking RASopathy mutations to peripheral nerve dysfunction.

Multiple congenital malformations arise from somatic mosaicism for constitutively active Pik3ca signalling

This study investigates how somatic Pik3ca mutations in neural crest and related lineages cause congenital malformations and vascular anomalies in mice, with implications for human PIK3CA-related disorders.