MicrobiologyMicrobiologyPeer-reviewed journal article
Antiparasitic effect of peptoids against Cryptosporidium parvum
Bridget Lamont, Bruce RusselliD, Rossarin SuwanaruskiD, Josefine Eilsø NielseniD, Kristian SørenseniD, Deborah Bow Yue YungiD, Annelise E. BarroniD, Daniel PletzeriD, Morad‐Rémy Muhsin‐SharafaldineiD
Abstract
Cryptosporidiosis, caused by Cryptosporidium parvum, poses significant health risks, particularly for children and immunocompromised individuals. Current treatments are ineffective in these vulnerable groups. This study explores the antiparasitic effects of against C. parvum. Out of 14 synthetic peptidomimetics (peptoids) screened, TM9 and TM19 exhibited potent anti-cryptosporidial activity without harming host cells. These findings suggest that peptoids could be a promising new therapeutic avenue for cryptosporidiosis, warranting further investigation.
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- top 19%
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