Author

C. D. Huston

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:chicken / avian· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. E. Teixeira· 3 shared D. W. Griggs· 2 shared E. E. Stebbins· 2 shared M. M. Hasan· 2 shared P. J. Miller· 2 shared A. C. Cameron· 1 shared A. Cameron· 1 shared A. L. Greninger· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMicrobiology

J. E. Teixeira

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Author profile →

5 papers

Recent·Most cited

Cryptosporidium Life Cycle Small Molecule Probing Implicates Translational Repression And An Apetala 2 Transcription Factor In Sexual Differentiation

M. M. Hasan, E. B. Mattice, J. E. Teixeira, R. S. Jumani, E. E. Stebbins, C. E. Klopfer, S. E. Franco, M. S. Love, C. W. McNamara, C. D. Huston

This study identifies small-molecule compounds that modulate sexual differentiation in Cryptosporidium using a multi-readout imaging assay and confirms translational repression and an AP2 transcription factor's role in this process.

bioRxiv · Dec 18, 2023 · PreprintMicrobiology

Organoid-based in vitro system and reporter for the study of Cryptosporidium parvum sexual reproduction

B. R. Korwin-Mihavics, E. A. Dews, P. J. Miller, A. Cameron, B. Martorelli di Genova, C. D. Huston

This paper develops an organoid-based culture system and a fertilization reporter to study Cryptosporidium parvum sexual reproduction, enabling real-time observation and validation of fertilization and oocyst production.

bioRxiv · Sep 29, 2023Microbiology

Identification of potent and orally efficacious phosphodiesterase inhibitors in Cryptosporidium parvum-infected immunocompromised mice

J. E. Teixeira, M. Gasonoo, P. Miller, J. Ajiboye, A. C. Cameron, E. Stebbins, S. D. Campbell, D. W. Griggs, T. Spangenberg, M. J. Meyers, C. D. Huston

This study identifies potent PDE-V inhibitors effective against Cryptosporidium parvum in immunocompromised mice, with minimal off-target effects.

bioRxiv · Sep 26, 2023 · PreprintMicrobiology

Spontaneous selection of Cryptosporidium drug resistance in a calf model of infection

M. M. Hasan, E. E. Stebbins, R. K. M. Choy, J. R. Gillespie, E. de Hostos, P. J. Miller, A. Mushtaq, R. M. Ranade, J. E. Teixeira, C. L. M. J. Verlinde, A. Sateriale, Z. Zhang, D. M. Osbourn, D. W. Griggs, E. Fan, , C. D. Huston

This study reports the spontaneous emergence of drug resistance in Cryptosporidium parvum infected calves treated with a methionyl-tRNA synthetase inhibitor, highlighting the potential for anticryptosporidial resistance.

bioRxiv · Jan 4, 2021Microbiology

DIRECT RT-qPCR DETECTION OF SARS-CoV-2 RNA FROM PATIENT NASOPHARYNGEAL SWABS WITHOUT AN RNA EXTRACTION STEP

E. A. Bruce, M.-L. Huang, G. A. Perchetti, S. Tighe, J. J. Hoffman, P. Laaguiby, D. L. Gerrard, A. Nalla, Y. Wei, A. L. Greninger, S. A. Diehl, D. J. Shirley, D. G. B. Leonard, C. D. Huston, B. D. Kirkpatrick, , J. W. Botten

This paper tests a direct RT-qPCR method for detecting SARS-CoV-2 RNA in nasal swabs without RNA extraction, achieving 92% accuracy on blinded samples.

bioRxiv · Mar 20, 2020Microbiology