Annelise E. Barron

Investigation of Regulation and Binding Patterns of the Human Cathelicidin Peptide LL-37 in Complexation with Nucleic Acids, and its Impact on Neutrophil Extracellular Traps

This study investigates how LL-37 binds to nucleic acids, forming complexes that affect DNA structure and NET clearance, with implications for immune regulation and disease.

Identification of gingipains in glioblastoma tumors and evidence that P. gingivalis infection drives IL-6 and PD-L1 expression in glioma cells

This paper identifies elevated gingipain antigens in glioblastoma tissue and shows P. gingivalis infection increases IL-6 and PD-L1 expression, promoting immunosuppressive and invasive glioma cell behavior.

Antiparasitic effect of peptoids against Cryptosporidium parvum

This study identifies two peptoids, TM9 and TM19, with potent anti-Cryptosporidium parvum activity that does not harm host cells, suggesting their potential as new therapeutics for cryptosporidiosis.

Targeting intracellular of populations Pseudomonas aeruginosa with peptide-mimetic therapies: individual efficacy and synergistic rescue of obsolete antibiotics.

The paper develops a peptide-based therapy that targets intracellular Pseudomonas aeruginosa and synergizes with obsolete antibiotics to reduce bacterial reservoirs.

Time-resolved phenotyping at subcellular resolution reveals shared principles and key trade-offs across antimicrobial peptide activities

The paper develops a time-resolved single-cell pipeline to analyze antimicrobial peptides in E. coli, revealing two classes with opposing functional trade-offs in their mechanisms and efficacy against biofilms.

Pf bacteriophages hinder sputum antibiotic diffusion via electrostatic binding

This study shows Pf phages and sputum polymers reduce antibiotic diffusion through electrostatic binding and liquid crystal formation in chronic Pseudomonas aeruginosa infections.