The effects of long-term atorvastatin use on the cytoarchitecture of new and older neurons of sensorimotor nucleus HVC in a juvenile songbird model

Abstract

Introduction Introduction Materials and methods Results Discussion References Statins are a commonly-used class of cholesterol-lowering drugs which effectively reduce the production of plasma cholesterol by the liver, and thus are associated with reducing the risk of cardiovascular diseases (Horwich et al., 2004). However, cholesterol is also produced de novo in the brain, raising questions of whether oral statins that cross from the periphery into the brain impact brain cholesterol, neural tissue, and cognition (Eckert et al., 2001, Fong, 2014, Banach et al., 2017). The vast majority of research on statins and cognition convincingly demonstrate that many statins are neuroprotective and ameliorate cognitive decline in patients with neurodegenerative dise ...