Daniel Merk

Click. Screen. Degrade. A Miniaturized D2B Workflow for rapid PROTAC Discovery

This paper introduces a miniaturized PROTAC synthesis workflow that bypasses compound purification, enabling rapid screening and degradation assessment of multiple targets.

An aerosolised dual-action Autotaxin inhibitor- PPARγ agonist for the treatment of pulmonary fibrosis

This paper introduces EL244, a dual ATX inhibitor and PPARγ agonist for treating pulmonary fibrosis, showing reduced LPA levels and fibrosis in a bleomycin model.

RXR agonist S169 inhibits HBV/HDV entry in vitro by disrupting KIF4-dependent NTCP trafficking.

This study identifies S169, an RXR agonist, as an inhibitor of HBV/HDV entry by disrupting KIF4-dependent NTCP trafficking in human hepatocytes.

Nurr1 modulation mediates neuroprotective effects of statins

This study identifies Nurr1 modulation by statins as a mechanism underlying their neuroprotective effects, showing statins affect Nurr1 activity and induce neuroprotective mechanisms.