Interneuron subtypes enable independent modulation of excitatory and inhibitory firing rates after sensory deprivation

Abstract

Diverse interneuron subtypes determine how cortical circuits process sensory information depending on their connectivity. Sensory deprivation experiments are ideally suited to unravel the plasticity mechanisms which shape circuit connectivity, but have yet to consider the role of different inhibitory subtypes. We investigate how synaptic changes due to monocular deprivation affect the firing rate dynamics in a microcircuit network model of the visual cortex. We demonstrate that, in highly recurrent networks, deprivation-induced plasticity generates fundamentally different activity changes depending on interneuron composition. Considering parvalbumin-positive (PV+) and somatostatin-positive (SST+) interneuron subtypes can capture the experimentally observed independent modulation of excitatory and inhibitory activity during sensory deprivation when SST+ feedback is sufficiently strong. Our model also applies to whisker deprivation in the somatosensory cortex revealing that these mechanisms are general across sensory cortices. Therefore, we provide a mechanistic explanation for the differential role of interneuron subtypes in regulating cortical dynamics during deprivation-induced plasticity.