Nathaniel J Miska

Zapit provides an open-source platform for random-access laser-scanning optogenetics in mice, enabling user-friendly and accessible experiments.

This study examines age-related changes in neural and behavioural variability during a decision-making task in mice, finding increased neural variability and reduced variability quenching in specific brain regions.

Mice infer stimulus-side priors from recent choices; prior signals are decodable pre-stimulus in 24.0% to 30.2% of 242 brain regions, including early visual and motor areas.

The paper presents a brain-wide neural activity map from 621,733 neurons across 139 mice performing a decision-making task, showing how neural activity encodes task variables across brain regions.

The paper shows that mice with ASD-related mutations exhibit similar computational and neural anomalies in prior updating during decision-making.

This study evaluates the reproducibility of electrophysiological measurements across ten labs using standardized protocols and finds that variability in electrode targeting and statistical methods affects reproducibility.

The paper introduces two public websites for exploring large-scale electrophysiology data from the International Brain Laboratory, enabling cross-platform access to behavioral trials and neuronal data.

The paper describes a modular data architecture for a neuroscience collaboration, enabling data contribution, access, and analysis across multiple labs.

This paper introduces a video analysis tool that combines supervised pose estimation with unsupervised dimensionality reduction to extract interpretable behavioral features from animal videos, improving downstream analyses.

This paper develops a standardized task for measuring decision-making in mice, showing reproducible results across multiple laboratories and providing a public dataset and tools.

This study shows that Shank3 loss disrupts homeostatic plasticity and circuit stability, which can be rescued by lithium, suggesting a therapeutic target for Shankopathies.

The paper shows that sensory deprivation alters both feedforward and feedback excitation-inhibition ratios in layer 4 of V1, with feedback inhibition primarily causing reduced visual responsiveness.