Author

Alexander P.Y. Brown

Sainsbury Wellcome CentreORCID 0000-0002-3214-7977Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Approach:experimental assay· 1

Frequent Co-Authors

Lee CosselliD· 2 shared Troy W. MargrieiD· 2 shared Adam M. H. Young· 1 shared Damon Polioudakis· 1 shared Daniel H. GeschwindiD· 1 shared David H. RowitchiD· 1 shared Eric Jinsheng HuangiD· 1 shared Erik M. UllianiD· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

Lee CossellORCID

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3 papers

Recent·Most cited

Excitatory and inhibitory L2/3 neurons in mouse primary visual cortex are balanced in their input connectivity

Alexander P.Y. Brown, Lee Cossell, Troy W. Margrie

The paper quantifies the similarity in long-range presynaptic connectivity between excitatory and inhibitory L2/3 neurons in mouse V1, finding they receive input from similar brain regions in comparable proportions.

bioRxiv · Apr 21, 2020 · PreprintNeuroscience

Visual experience regulates the intrinsic excitability of visual cortical neurons to maintain sensory function

Alexander P.Y. Brown, Lee Cossell, Troy W. Margrie

This study shows that visual input modifies intrinsic excitability of visual cortical neurons in mice, compensating for changes in synaptic drive to maintain sensory function.

Cell Reports · Apr 1, 2019Peer-reviewedNeuroscience

Single-cell in situ transcriptomic map of astrocyte cortical layer diversity

Omer Ali Bayraktar, Theresa Bartels, Damon Polioudakis, Staffan Holmqvist, Lucile Ben Haim, Adam M. H. Young, Kirti Prakash, Alexander P.Y. Brown, Mercedes F. Paredes, Riki Kawaguchi, John H. Stockley, Khalida Sabeur, Sandra Chang, Eric Jinsheng Huang, Peter J. Hutchinson, , David H. Rowitch

The paper maps astrocyte layer diversity in the cortex using a high-content spatial transcriptomic pipeline, revealing distinct astrocyte identities and their relationship to neuronal organization.

bioRxiv · Oct 3, 2018 · PreprintNeuroscience