bioRxivMicrobiology
Putative conjugative plasmids with tcdB and cdtAB genes in clinical Clostridium difficile strains 2 from MLST clades C-I, 2 and 4
Abstract
The major toxins of Clostridium difficile (TcdA, TcdB, CDT) are encoded chromosomally in nearly all known strains. Following up on a previous report, we found five new examples of a family of putative conjugative plasmids with tcdB and cdtAB in clinical C. difficile isolates from MLST Clades C-I, 2, and 4.
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Carriage of three plasmids in a single human clinical isolate of Clostridioides difficile
A. M. Roseboom, Q. R. Ducarmon, … W. K. Smits·bioRxiv·Jul 10, 2022
- Phylogenomics of 8,839 Clostridioides difficile genomes reveals recombination-driven evolution and diversification of toxin A and B
M. J. Mansfield, B. J.-M. Tremblay, … A. C. Doxey·bioRxiv·Jul 9, 2020
- An in silico survey of Clostridioides difficile extrachromosomal elements
B. V. H. Hornung, E. J. Kuijper, W. K. Smits·bioRxiv·May 29, 2019
- A streamlined method to obtain biologically active TcdA and TcdB toxins from Clostridioides difficile
A. A. D. Sapa, A. Brosse, … A. Le Monnier·bioRxiv·Jul 19, 2023
- The C-terminal domain of Clostridioides difficile TcdC is exposed on the bacterial cell surface
A. M. oliveira paiva, L. de Jong, … J. Corver·bioRxiv·Dec 11, 2019
- A helicase-containing module defines a family of pCD630-like plasmids in Clostridium difficile
W. K. Smits, J. S. Weese, … B. Hornung·bioRxiv·Nov 2, 2017