Author

A. C. Doxey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:bulk RNA-seq· 5 Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Organism:C. elegans· 1

Frequent Co-Authors

J. A. Hirota· 5 shared B. J.-M. Tremblay· 4 shared J. A. Aguiar· 4 shared K. Ask· 4 shared S. Revill· 4 shared A. Banerjee· 3 shared M. J. Mansfield· 3 shared M. S. Miller· 3 shared

Activity by Year

2020-2022 · peak 7/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersImmunology

J. A. Hirota

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Genomic and transcriptomic characterization of Delta SARS-CoV-2 infection in free-ranging white-tailed deer (Odocoileus virginianus)

J. D. Kotwa, B. Lobb, A. Masse, M. Gagnier, P. Aftanas, A. Banerjee, A. Banete, J. Blais-Savoie, J. Bowman, T. Buchanan, H.-Y. Chee, P. Kruczkiewicz, F. Maguire, A. J. McGeer, K. Nirmalarajah, , S. Mubareka

The paper characterizes Delta SARS-CoV-2 infection in white-tailed deer using genomic and transcriptomic analyses, identifying mutations and host immune responses.

bioRxiv · Jan 20, 2022Microbiology

Structure-function analysis of distant diphtheria toxin homologs reveals insights into host adaptation

S. N. Sugiman-Marangos, S. K. Gill, M. J. Mansfield, K. E. Orrell, A. C. Doxey, R. A. Melnyk

The paper determines high-resolution structures of DT homologs to investigate their host adaptation and toxicity mechanisms.

bioRxiv · Aug 10, 2021 · PreprintMicrobiology

Potentiation of Long-Acting β2-Agonist and Glucocorticoid Responses in Human Airway Epithelial Cells by Modulation of Intracellular cAMP

Y. Kim, V. Hou, R. D. Huff, J. A. Aguiar, S. Revill, N. Tiessen, C. Cao, M. S. Miller, M. D. Inman, K. Ask, A. C. Doxey, J. A. Hirota

This study shows that inhibiting PDE4 or ABCC4 enhances the anti-inflammatory effects of LABA/GCS in human airway epithelial cells exposed to viral stimuli.

bioRxiv · Nov 9, 2020Immunology

Phylogenomics of 8,839 Clostridioides difficile genomes reveals recombination-driven evolution and diversification of toxin A and B

M. J. Mansfield, B. J.-M. Tremblay, J. Zeng, X. Wei, H. Hodgins, J. Worley, L. Bry, M. Dong, A. C. Doxey

This study analyzes 8,839 C. difficile genomes to reveal recombination-driven evolution of toxins A and B, develops a subtyping method, and creates a database for therapeutic and research use.

bioRxiv · Jul 9, 2020Microbiology

Experimental and natural evidence of SARS-CoV-2 infection-induced activation of type I interferon responses

A. Banerjee, N. El-Sayes, P. Budylowski, D. Richard, H. Maan, J. Aguiar, K. Baid, M. R. D'Agostino, J. C. Ang, B. J.- M. Tremblay, S. Afkhami, M. Karimzadeh, A. T. Irving, L. Yip, M. A. Ostrowski, , K. Mossman

This study shows SARS-CoV-2 infection induces a mild type I IFN response in vitro and in moderate COVID-19 cases, and cannot inhibit exogenous IFN induction.

bioRxiv · Jun 18, 2020Immunology

Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue

J. A. Aguiar, B. J.-M. Tremblay, M. J. Mansfield, O. Woody, B. Lobb, A. Banerjee, A. Chandiramohan, N. Tiessen, A. Dvorkin-Gheva, S. Revill, M. S. Miller, C. Carlsten, L. Organ, C. Joseph, A. John, , J. A. Hirota

The paper examines gene expression and protein localization of potential SARS-CoV-2 receptors in human airway epithelial cells and lung tissue, finding low ACE2 expression and confirming other candidate receptors.

bioRxiv · Apr 7, 2020Immunology

Expression of the endocannabinoid system in the human airway epithelial cells: Impact of sex and chronic respiratory disease status

M. F. Fantauzzi, J. A. Aguiar, B. J.-M. Tremblay, T. Yanagihara, A. Chandiramohan, S. Revill, M. H. Ryu, C. Carlsten, K. Ask, M. Stampfli, A. C. Doxey, J. A. Hirota

The paper analyzes gene expression of the endocannabinoid system in human airway epithelial cells, showing differential expression by disease status and minimal sex impact.

bioRxiv · Mar 1, 2020Cell Biology

ABCF1 regulates dsDNA-induced immune responses in human airway epithelial cells

Q. T. Cao, J. A. Aguiar, B. J.-M. Tremblay, N. Abbas, N. Tiessen, S. Revill, N. Makhdami, A. Ayoub, G. Cox, K. Ask, A. C. Doxey, J. A. Hirota

This study identifies ABCF1 as a cytosolic nucleic acid sensor in human airway epithelial cells that modulates antiviral responses and interacts with TLR signaling.

bioRxiv · Feb 8, 2020Immunology

High functional diversity among Nitrospira populations that dominate rotating biological contactor microbial communities in a municipal wastewater treatment plant

E. Spasov, J. M. Tsuji, L. A. Hug, A. C. Doxey, L. A. Sauder, W. J. Parker, J. D. Neufeld

This study identifies high functional diversity among Nitrospira populations in wastewater treatment plant biofilms, revealing distinct metabolic capabilities and spatial distributions.

bioRxiv · Jan 20, 2020Microbiology