Game theoretic methods in population dynamics

Game theoretic methods are used to model the dynamics of cellular populations (tissues) in which it is necessary to account for changes in cellular phenotype (usually proliferation) resulting from cell-cell interaction. Results include prediction of long-term steady-state \"equilibria\" and transient dynamics. These results can be useful for predicting relapse after cytoreduction, assessing the efficacy of alternating combination therapy, and interpreting biopsy specimens obtained from spatially heterogeneous tissues. Mathematical tools range from simple systems of differential equations to computational techniques (individual-based models).