P. M. Altrock

Paracrine enhancement of tumor cell proliferation provides indirect stroma-mediated chemoresistance via acceleration of tumor recovery between chemotherapy cycles.

The paper investigates how stromal factors indirectly enhance tumor chemoresistance by accelerating tumor recovery between chemotherapy cycles through paracrine signaling.

Intra-tumor heterogeneity, turnover rate and karyotype space shape susceptibility to missegregation-induced extinction

The paper models chromosome missegregation in tumors to assess extinction risk, finding that intra-tumor heterogeneity and karyotype stability prevent extinction unless turnover rates are extremely high.

Autocrine signaling explains the emergence of Allee effects in cancer cell populations

This study shows autocrine signaling can cause Allee effects in cancer cell populations, with growth rates depending on population density and death-to-proliferation ratios.

Spatial Clustering of CD68+ Tumor Associated Macrophages with Tumor Cells is Associated with Worse Overall Survival in Metastatic Clear Cell Renal Cell Carcinoma

The paper quantifies cellular density and clustering of immune cells in metastatic ccRCC and finds that CD68+ TAM clustering with tumor cells correlates with worse overall survival.

Branching and extinction in evolutionary public goods games

This study investigates how cooperation and defection emerge in nonlinear local public goods games through evolutionary branching and population size effects.

High school Internship Program in Integrated Mathematical Oncology (HIP IMO) - five-year experience at Moffitt Cancer Center

The paper describes a high school internship program in mathematical oncology, detailing its structure, curriculum, and outcomes over five years.

The Harsh Microenvironment in Early Breast Cancer Selects for a Warburg Phenotype

The paper investigates how harsh microenvironments in early breast cancer select for a Warburg phenotype through metabolic and transcriptomic changes.

Response to CAR T cell therapy can be explained by ecological cell dynamics and stochastic extinction events

The paper develops a mathematical model to explain CAR T cell therapy outcomes by integrating ecological dynamics and stochastic extinction events, showing tumor eradication is a stochastic process.

Spontaneous Cell Fusions as a Mechanism of Parasexual Recombination in Tumor Cell Populations

This study investigates spontaneous cell fusions in tumor cell populations as a mechanism of parasexual recombination, finding evidence of low-frequency fusions and their role in increasing clonal heterogeneity.

Modeling adaptive therapy in non-muscle invasive bladder cancer

This study models adaptive therapy for non-muscle invasive bladder cancer to control tumor size and reduce recurrence by analyzing mutational heterogeneity and cytokine profiles.

Predictive modeling of co-evolving growing populations

The paper explores density and frequency dependence in tumor growth dynamics using predictive modeling and treatment outcomes.

Persistence of cooperation in diffusive public goods games

This study analyzes the persistence of cooperation in diffusive public goods games by deriving a finite-size correction that relates model parameters to long-term cooperation.

Leveraging single cell RNA sequencing experiments to model intra-tumor heterogeneity

This study introduces a generalized diversity index (GDI) to quantify intra-tumor heterogeneity using single-cell RNA sequencing data and demonstrates its utility across various cancer types and conditions.

Extinction Rates In Tumor Public Goods Games

The paper shows that standard replicator dynamics may not capture equilibrium timescales in tumor evolution due to overlooked population growth effects.