Bioactivity of Aqueous Extract of Pulp of Crysophyllum albidium (G. Don-Holl.) on Isoproterenol Treated Albino Rats

Abstract

Cardiovascular disorder is one of the causes of death globally. Quite a number of medicinal plants have been demonstrated to possess and exhibit beneficial effects on cardiovascular system throuhg their antioxidant properties. The study investigated the in vivo antioxidant properties of aqueous C. albidium pulp extract on isoproterenol-induced cardiotoxicity in albino rats. Cardiotoxicity was induced in rats by subcutaneous injection of ISO (85 mg/kg bwt) into adult albino rats and treated with the extract (100 and 200 mg/kg bwt). The levels of nitrite, lipid peroxidation, reduced glutathione total protein and activities of glutathione peroxidase, catalase and superoxide dismutase were evaluated using standard methods. The concentration of total protein was also determined. Administration of ISO (85 mg/kg body weight) caused significant (p < 0.05) reduction in the antioxidant status of animals. The enzymatic and non-enzymatic antioxidants perturbed by the administration of ISO were restored in the C. albidium treated rats. The study concludes that the aqueous extract of C. albidum pulp protected against Isoproterenol-induced cardiotoxicity in adult male Albino rats.