C.-C. Lin

Protein CoAlation on TXNRD2 regulates mitochondrial thioredoxin system to protect against ferroptosis

This study identifies CoA-mediated post-translational modification of TXNRD2 as a novel mechanism regulating the mitochondrial thioredoxin system to protect against ferroptosis.

CD39 is expressed on functional effector and tissue resident memory CD8+ T cells

This study identifies CD39 expression on functional effector and tissue-resident memory CD8+ T cells, showing its role in memory differentiation and function, distinct from its role in T cell exhaustion.

NINJ1 regulates ferroptosis via xCT antiporter interaction and CoA modulation

This paper shows NINJ1 protects cancer cells from ferroptosis by interacting with xCT antiporter and modulating CoA and GSH levels.

Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins

The paper identifies osteosarcoma-enriched transcripts that encode extracellular tumor-suppressing proteins, suggesting a paradoxical therapeutic strategy using OS transcriptomes.

Mre11 liberates cGAS from nucleosome sequestration during tumorigenesis

Mre11 facilitates cGAS activation by displacing it from nucleosome sequestration, promoting ZBP1-dependent necroptosis and suppressing tumor growth.

The evolution and structure of snake venom phosphodiesterase (svPDE) highlight its importance in venom actions

This study investigates the evolution and structure of snake venom phosphodiesterase (svPDE), showing it evolved from the ENPP3 gene and plays a key role in venom function through purinergic signaling and insulin transduction.

Fragment Linker Prediction Using Deep Encoder-Decoder Network for PROTAC Drug Design

This paper introduces AIMLinker, a deep learning model that generates PROTACs analogs with improved chemical properties by integrating structural filters and molecular docking validation.

Structural analyses of the plant PRT6-UBR box in the Cys-Arg/N-degron pathway and insights into the plant submergence response

This study determines the structure of PRT6-UBR box in rice and Arabidopsis and identifies conserved motifs critical for Cys-Arg/N-degron recognition, showing that modifying these motifs improves submergence tolerance in Arabidopsis.

Expansion microscopy reveals subdomains in C. elegans germ granules

This study uses expansion microscopy to reveal subdomains within C. elegans P granules and their relationship to other germ granules.

Omicron-specific mRNA vaccine induced potent neutralizing antibody against Omicron but not other SARS-CoV-2 variants

This study evaluates Omicron-specific mRNA vaccines and finds they induce strong neutralizing antibodies against Omicron but not other variants, while bivalent vaccines show broader neutralizing activity.

Dissolvable microgel-templated macroporous hydrogels for controlled cell assembly

This paper develops a method to create cell-laden macroporous hydrogels using dissolvable microgels, enabling controlled cell assembly and secretion of growth factors.

Calcium-binding protein S100A6 interaction with VEGF receptors integrates signaling and trafficking pathways

This study identifies S100A6 as a calcium-dependent regulator of VEGFR trafficking and signaling, integrating these processes in endothelial cell responses to VEGF-A.

Molecular insights into substrate recognition and discrimination by the N-terminal domain of Lon AAA+ protease

This study investigates how the N-terminal domain of Lon AAA+ protease recognizes and discriminates substrates through hydrophobic patches and flexible linkers.

Multi-omics approach to identify bacterial polyynes and unveil their antifungal mechanism against Candida albicans

This study identifies a bacterial polyyne resistance gene and elucidates its antifungal mechanism against Candida albicans using multi-omics approaches.

Regulation of kinase activity by combined action of juxtamembrane and C-terminal regions of receptors

The paper investigates how juxtamembrane and C-terminal regions regulate kinase activity in RTKs, identifying key interactions and mutations linked to disease.

Hemodynamic and electromechanical effects of paraquat in rat heart

This study investigates the cardiotoxic effects of paraquat in rats, finding dose-dependent decreases in heart function and QTc interval prolongation due to impaired calcium transients and potassium channel activity.

Parkin coordinates mitochondrial lipid remodeling to execute mitophagy

This study shows Parkin orchestrates mitochondrial lipid remodeling through phospholipase D2 and Lipin-1 to drive mitophagy via DAG production and autophagosome formation.

Characterization of the dimeric interactions of dimeric and tetrameric conformations of the PvNV protrusion-domain using a mixed DFT/QTAIM approach

The paper uses a mixed DFT/QTAIM approach to analyze dimeric and tetrameric interactions in the PvNV P-domain, identifying key residue pairs and interaction types.

G9a Promotes Breast Cancer Recurrence Through Repression of a Pro-inflammatory Program

This study shows that G9a promotes breast cancer recurrence by repressing pro-inflammatory genes, leading to necroptosis when inhibited.

Grb2 binding induces phosphorylation-independent activation of Shp2

This study shows Grb2 binding activates Shp2 independently of phosphorylation, and identifies a peptide that blocks this interaction, reducing Shp2 activity and MAPK signaling.

Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state

This study shows that RTKs form liquid-liquid phase-separated states with downstream effectors to enhance signaling fidelity.

RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrence

This study identifies RIPK3 upregulation in recurrent breast tumors, showing it promotes proliferation but also creates dependence on cystine, offering new therapeutic targets.

Direct interaction of PIWI and DEPS-1 is essential for piRNA function and condensate ultrastructure in Caenorhabditis elegans

The paper investigates how PIWI and DEPS-1 interact to support piRNA function and condensate structure in C. elegans.