bioRxivBiophysicsPreprint
13C and 15N Resonance Assignments of Alpha Synuclein Fibrils Amplified from Lewy Body Dementia Tissue
A. M. Barclay, D. D. Dhavale, C. G. Borcik, M. H. Milchberg, P. T. Kotzbauer, C. M. Rienstra
Abstract
Fibrils of the protein -synuclein (Asyn) are implicated in the pathogenesis of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. Numerous forms of Asyn fibrils have been studied by solid-state NMR and resonance assignments have been reported. Here, we report a new set of 13C, 15N assignments that are unique to fibrils obtained by amplification from postmortem brain tissue of a patient diagnosed with Lewy Body Dementia.
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