Melek Firat Altay

SysNDD is a curated database of gene-disease associations for neurodevelopmental disorders, providing standardized evidence and annotations for 4,275 entities from 4,932 publications.

This study investigates how C-terminal truncations of alpha-synuclein (aSyn) affect Lewy body (LB) formation and pathology in Parkinson's disease by analyzing their role in fibril processing and aggregation.

The paper develops and validates an expanded antibody panel to capture diverse alpha-synuclein conformations and modifications in Lewy body diseases.

The paper investigates astrocytic alpha-synuclein pathology in Lewy body disorders, revealing unique post-translational modification signatures and distribution patterns.

The paper shows that neighboring post-translational modifications affect the detection of phosphorylated alpha-synuclein at Serine 129 by existing antibodies.

The paper examines post-translational modifications of alpha-synuclein in Parkinson's disease and Multiple System Atrophy using immunohistochemistry to identify predominant PTMs in pathological aggregates.

Calpain-1/2 cleavage of the alpha-synuclein C-terminus after fibril formation is reported to drive seeding, aggregation and the maturation of Lewy-body-like inclusions in primary neurons.