Author

T. F. Outeiro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Pathology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

D. Erskine· 2 shared J. Attems· 2 shared A. A. Chouaib· 1 shared A. E. Dorn· 1 shared A. H. Shaib· 1 shared A. Porter· 1 shared A. R. A. Aricescu· 1 shared B. McFarland· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersPathology

D. Erskine

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Author profile →

4 papers

Recent·Most cited

Impact of Phosphorylation on the Physiological Form of Human alpha-Synuclein in Aqueous Solution

E. de Bruyn, A. E. Dorn, G. Rossetti, C. Fernandez, T. F. Outeiro, J. B. Schulz, P. Carloni

This study uses molecular simulations to investigate how phosphorylation at serine 129 affects the structure of human alpha-synuclein in aqueous solution, finding no significant impact on its conformational ensemble.

bioRxiv · Mar 10, 2023Biophysics

Visualizing proteins by expansion microscopy

A. H. Shaib, A. A. Chouaib, R. Chowdhury, D. Mihaylov, C. Zhang, V. Imani, S. V. Georgiev, N. Mougios, M. Monga, S. Reshetniak, T. Mimoso, H. Chen, P. Fatehbasharzad, D. Crzan, N. Alawar, , S. Rizzoli

This paper introduces ONE microscopy, a technique that enables nanoscale imaging of single proteins and molecular complexes, revealing structural details in cells and disease samples.

bioRxiv · Aug 3, 2022Biophysics

Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies

D. J. Koss, D. Erskine, A. Porter, P. Palmowski, M. Leite, J. Attems, T. F. Outeiro

This study confirms the presence of nuclear alpha-synuclein in human brain tissue from dementia with Lewy bodies cases and identifies its aggregation into pathological assemblies in the nucleus.

bioRxiv · Oct 20, 2021 · PreprintPathology

Prion-like α-synuclein pathology in the brains of infants: Krabbe disease as a novel seed-competent α-synucleinopathy

C. Hatton, S. S. Ghanem, D. Koss, I. Y. Abdi, E. Gibbons, R. Guerreiro, J. Bras, International DLB Genetics Consortium, L. Walker, E. Gelpi, W. Heywood, T. F. Outeiro, J. Attems, B. McFarland, R. Forsyth, , D. Erskine

This study shows that α-synuclein in Krabbe disease brains can seed fibrillar aggregates similar to Lewy body diseases, indicating prion-like properties in infants.

bioRxiv · Oct 12, 2021 · PreprintPathology