bioRxivCancer Biology
Modelling 3D tumour microenvironment in vivo: a tool to predict cancer fate
Abstract
Recently, many studies demonstrated the fundamental role of tumour microenvironment (TME) in cancer progression. Here, we describe a state-of-the-art method to visualize in 3D the behaviour of tumours in zebrafish embryos. We highlight two major actors of TME, macrophages and vessels. This valuable tool is transposable to Patients Derived Xenograft imaging in order to predict the fate of malignant tumours according to the dynamics of their TME.
- organism: zebrafish
- assay: imaging
- research focus: cancer & tumor microenvironment
- approach: experimental assay
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Studying the fate of tumor extracellular vesicles at high spatio-temporal resolution using the zebrafish embryo
V. Hyenne, S. Ghoroghi, … J. G. Goetz·bioRxiv·Jul 30, 2018
- Melanoma innervation is associated with cancer progression in a zebrafish xenograft model
F. LORENZINI, J. MARINES, … K. KISSA·bioRxiv·Dec 13, 2023
- Continuous high-resolution in vivo imaging reveals tumor-specific dissemination in an embryonic zebrafish xenograft model
N Asokan, S Daetwyler, … M Bornhäuser·bioRxiv·Nov 8, 2017
- In vivo imaging defines vascular interplay in the development of lymphocytic leukemia in zebrafish models
S. Revskoy, M. E. Blair, … J. S. Blackburn·bioRxiv·Oct 16, 2019
- Tumor-on-a-chip platform to interrogate the role of macrophages in tumor progression
Y. Bi, V. S. Shirure, … R. C. Fields·bioRxiv·May 27, 2020
- Targeting human M2 macrophages with antibodies in optimized 3D tumor spheroids
Chloe Bazile, Fabien Gava, … Mary Poupot·bioRxiv·Sep 16, 2025