Author

V. S. Shirure

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

S. C. George· 5 shared B. S. Shergill· 2 shared B. Shergill· 2 shared P. A. Sariano· 2 shared Z. A. Rollins· 2 shared A. Anand· 1 shared A. Brandt· 1 shared A. M. Alhassan· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersBioengineering

S. C. George

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A microfluidic strategy to capture antigen-specific high affinity B cells

A. M. Alhassan, V. S. Shirure, J. Luo, B. B. Nguyen, Z. A. Rollins, B. S. Shergill, X. Zhu, N. Baumgarth, S. C. George

This paper introduces a microfluidic method to assess B cell affinity to antigens under force, showing it can enrich high-affinity B cells and correlate with solution-based antibody affinity.

bioRxiv · Jul 12, 2023Bioengineering

Convection and extracellular matrix binding control interstitial transport of extracellular vesicles

P. A. Sariano, R. Mizenko, V. S. Shirure, A. Brandt, C. Nesiri, B. Shergill, D. M. Rocke, R. P. Carney, S. C. George

This study shows that convection and ECM binding are the main mechanisms controlling EV transport in interstitial fluid, with implications for nanotherapeutic design.

bioRxiv · Aug 3, 2022Bioengineering

A vascularized 3D model of the human pancreatic islet for ex vivo study of immune cell-islet interaction

R. H. F. Bender, B. T. O'Donnell, B. Shergill, B. Q. Pham, D. J. Juat, M. S. Hatch, V. S. Shirure, M. Wortham, K.-V. Nguyen-Ngoc, Y. Jun, R. Gaetani, K. L. Christman, L. Teyton, S. C. George, M. Sander, C. C. Hughes

This paper develops a vascularized 3D model of human pancreatic islets to study immune cell interactions and islet destruction in diabetes.

bioRxiv · Dec 21, 2021Cell Biology

Tumor-on-a-chip platform to interrogate the role of macrophages in tumor progression

Y. Bi, V. S. Shirure, R. Liu, C. Cunningham, L. Ding, M. Meacham, P. Goedegebuure, S. C. George, R. C. Fields

This study uses a tumor-on-a-chip platform to show that M1 macrophages inhibit tumor growth and angiogenesis, while M2 macrophages promote tumor migration and angiogenesis through distinct molecular mechanisms.

bioRxiv · May 27, 2020Cancer Biology

Organ-on-a-chip model of vascularized human bone marrow niches

D. E. Glaser, M. B. Curtis, P. A. Sariano, Z. A. Rollins, B. S. Shergill, A. Anand, A. M. Deely, V. S. Shirure, L. Anderson, J. M. Lowen, N. R. Ng, K. Weilbaecher, D. C. Link, S. C. George

This study develops a 3D organ-on-a-chip model of human bone marrow niches that supports hematopoietic stem cell maintenance, differentiation, and myeloid progenitor egress.

bioRxiv · Apr 17, 2020Bioengineering