Y. Bi

Leveraging genomics and temporal high-throughput phenotyping to enhance association mapping and yield prediction in sesame

This study uses high-throughput phenotyping and genomic models to improve yield prediction in sesame by analyzing temporal trait dynamics and multi-trait associations.

Nuclear Pyruvate Dehydrogenase Complex Regulates Histone Acetylation and Transcriptional Regulation in the Ethylene Response

This study identifies the nuclear pyruvate dehydrogenase complex (PDC) as a key regulator of histone acetylation and transcription during ethylene response in plants.

Geranylgeranyl pyrophosphate (GGPP) is associated with hepatic lipid accumulation and insulin resistance in MAO by prenylating Perilipin4

This study shows GGPP promotes hepatic lipid accumulation and insulin resistance in MAO by prenylating Perilipin4, and inhibiting GGPP synthase reduces these effects.

Structure-based virtual screening identifies small molecule inhibitors of O-fucosyltransferase SPINDLY

The paper identifies SOFTI, a specific inhibitor of SPY O-fucosyltransferase, through virtual screening and validates its effects on O-fucosylation in Arabidopsis and tomato.

Autologous humanized PDX modeling for immuno-oncology recapitulates the human tumor microenvironment

This study develops an autologous humanized PDX model to study tumor-immune interactions and demonstrates its utility in preclinical testing by showing VEGF-A inhibition reduces tumor growth.

Dendritic cell Piezo1 integrating mechanical stiffness and inflammatory signals directs the differentiation of TH1 and Treg cells in cancer

Deconvoluting signals downstream of growth and immune receptor kinases by phosphocodes of the BSU1 family phosphatases

This study shows that BSU1 phosphatase uses different phosphorylation sites to transduce signals from brassinosteroid and flagellin receptors in plants.

Investigating the active substance and mechanism of Jing-Fu-Kang granules via mass spectrometry technology and network pharmacology method

This study identifies 97 chemical constituents of Jing-Fu-Kang granules and reveals 531 common targets and 136 pathways involved in its mechanism for cervical spondylosis using mass spectrometry and network pharmacology.

A recombinant receptor-binding domain in trimeric form generates completely protective immunity against SARS-CoV-2 infection in nonhuman primates

This study develops a trimeric RBD vaccine that induces long-term immunity and complete protection against SARS-CoV-2 in nonhuman primates.

A tandem-repeat dimeric RBD protein-based COVID-19 vaccine ZF2001 protects mice and nonhuman primates

ZF2001, a tandem-repeat dimeric RBD protein vaccine, induces strong immune responses and protects mice and non-human primates from SARS-CoV-2 infection.

Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses

The paper identifies novel bat coronaviruses, including relatives of SARS-CoV-2, from a region in China, providing insights into their evolutionary origins and geographic distribution.

Recombinant chimpanzee adenovirus AdC7 expressing dimeric tandem-repeat RBD of SARS-CoV-2 spike protein protects mice against COVID-19

This study evaluates a recombinant chimpanzee adenovirus vaccine expressing a dimeric tandem-repeat RBD of SARS-CoV-2, showing enhanced immune responses and protection in mice.

A potent synthetic nanobody targets RBD and protects mice from SARS-CoV-2 infection

Tumor-on-a-chip platform to interrogate the role of macrophages in tumor progression

This study uses a tumor-on-a-chip platform to show that M1 macrophages inhibit tumor growth and angiogenesis, while M2 macrophages promote tumor migration and angiogenesis through distinct molecular mechanisms.

A novel bat coronavirus reveals natural insertions at the S1/S2 cleavage site of the Spike protein and a possible recombinant origin of HCoV-19

This paper identifies a novel bat coronavirus, RmYN02, with sequence similarities to HCoV-19 and natural insertions at the S1/S2 cleavage site, suggesting a possible recombinant origin for HCoV-19.

A novel xenograft model of human HCC in immunocompetent mouse

This paper establishes a novel human HCC patient-derived xenograft model in immunocompetent mice, showing high tumor formation rates and preserved tumor characteristics.

Novel haplotypes and networks of AVR-Pik alleles in Magnaporthe oryzae

The paper identifies novel haplotypes and evolutionary pathways of AVR-Pik alleles in Magnaporthe oryzae using DNA sequence analysis and field-based avirulence testing.

Genome wide screen reveals a specific interaction between autosome and X that is essential for hybrid male sterility

The paper identifies multiple interacting genomic loci responsible for asymmetric hybrid male sterility and inviability between Caenorhabditis briggsae and C. nigoni.

Structural insight into the mechanism of neuraminidase inhibitor-resistant mutations in human-infecting H10N8 Influenza A virus

This paper identifies two drug-resistant mutations in H10N8 influenza virus and explains their structural mechanisms using crystallography, showing differences in resistance to neuraminidase inhibitors.