Cortical microinfarcts caused by single penetrating vessel occlusion lead to widespread reorganization across the entire brain in a CX3CR1 dependent manner

1. Introduction 1. Introduction 2. Results 3. Discussion 4. Methods and Materials 6. Author Contribution 7. Competing interests References Dementia, and the associated cognitive impairment that goes along with it, have been attributed to a plethora of different mechanisms. As proper brain function is tightly coupled with the on-demand supply of oxygen and nutrients to active areas, perturbation to blood flow and the resulting neurovas-cular uncoupling play a crucial role in the ethology of these pathologies [1, 2, 3], even before the onset of the clinical symptoms [4]. Although research has traditionally focused on systemic and large-scale perturbations such as hypertension and stroke, cortical microinfarcts emerge nowaday ...