Franca Schmid

Graph-Based Classification of Penetrating Cortical Arteries and Veins in Whole-Mouse Vasculature Datasets

The paper develops a graph-based classifier to distinguish arteries from veins in whole-brain vascular datasets, achieving high accuracy across imaging modalities.

Loss of Cerebral Autoregulation After Stroke Drives Abnormal Perfusion Patterns

This study develops an in silico model to simulate cerebral blood flow in mice with and without leptomeningeal collaterals, showing that myogenic reactivity, not collateral extent, drives hyperperfusion after stroke.

Blood Pressure Regulates Functional Coupling of L-Type Ca2+ Channels: Reimaging the Foundation of Cerebral Blood Flow Control.

This study identifies a pressure-sensitive regulatory mechanism of L-type Ca2+ channels that influences cerebral blood flow control and cognitive function.

Impaired capillary-venous drainage contributes to gliosis and demyelination in white matter during aging

The paper shows that impaired capillary-venous drainage in aging mice leads to hypoperfusion, gliosis, and demyelination in deep white matter regions.

Pericyte remodeling is deficient in the aged brain and contributes to impaired capillary flow and structure

This study shows that pericyte loss in aged brains leads to capillary dilation, flow heterogeneity, and structural disruption, highlighting pericyte remodeling as a therapeutic target.

The severity of microstrokes depends on local vascular topology and baseline perfusion

The paper uses blood flow simulations in mouse cortical microvascular networks to show that microstroke severity depends on local vascular topology and baseline perfusion.