Protein ScienceBioinformaticsPeer-reviewed journal article
Dual-wield NTPases: a novel protein family mined from AlphaFold DB
Abstract
AlphaFold protein structure database (AlphaFold DB) archives a vast number of predicted models. We conducted systematic data mining against AlphaFold DB and discovered an uncharacterized P-loop NTPase family. The structure of the protein family was surprisingly novel, showing an atypical topology for P-loop NTPases, noticeable two-fold symmetry and two pairs of independent putative active sites. Our findings show that structural data mining is a powerful approach to identifying undiscovered protein families.
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- top 49%
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