bioRxivImmunologyPreprint
The expression of PDCD1 and CD274 in T cells and macrophages correlated positively with COVID-19 severity
Q. Gao, S. Liu, R. Ding, H. Chen, X. Dong, J. Xie, Y. Li, L. Chen, H. Liu, F. Mu
Abstract
The immune responses underlying the infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain unclear. To help understand the pathology of coronavirus disease 2019 (COVID-19) pandemics, public data were analyzed and the expression of PDCD1 (encoding PD-1) and CD274 (encoding PD-L1) in T cells and macrophages were identified to correlate positively with COVID-19 severity.
- organism: human
- assay: bulk RNA-seq
- research focus: host-pathogen & immune response
- approach: statistical model
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Distinct SARS-CoV-2 sensing pathways in pDCs driving TLR7-antiviral vs. TLR2-immunopathological responses in COVID-19
R. M. van der Sluis, L. B. Cham, … M. R. Jakobsen·bioRxiv·Nov 23, 2021
- Lasting alterations in monocyte and dendritic cell subsets in individuals after hospitalization for COVID-19
F. R. Hopkins, M. Govender, … M. Larsson·bioRxiv·Jul 15, 2022
- Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection
A. Perez-Gomez, J. Vitalle, … E. Ruiz-Mateos·bioRxiv·Mar 18, 2021
- Impaired function and delayed regeneration of dendritic cells in COVID-19
E. Winheim, L. Rinke, … A. B. Krug·bioRxiv·May 26, 2021
- Single-cell transcriptome analysis of the immunosuppressive effect of differential expression of tumor PD-L1 on responding TCR-T cells
- Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patients
L. Rausch, K. Lutz, … T. Brocker·Journal of Extracellular VesiclesPeer-reviewed·Dec 1, 2021