Author

M. R. Jakobsen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

K. R. Gammelgaard· 2 shared A. Etzerodt· 1 shared A. G. Gheorghe· 1 shared A. G. Oliver· 1 shared A. Laustsen· 1 shared A. S. Hansen· 1 shared B. G. Fritz· 1 shared B. W. Deleuran· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

K. R. Gammelgaard

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Biofilms and core pathogens shape the tumour microenvironment and immune phenotype in colorectal cancer

L. Kvich, B. G. Fritz, H. Zschach, T. Terkelsen, H. Raskov, K. Hoest-Rasmussen, M. R. Jakobsen, A. G. Gheorghe, I. Gogenur, T. Bjarnsholt

The paper investigates how biofilms and core pathogens like Bacteroides fragilis and Fusobacterium nucleatum influence the tumor microenvironment and immune phenotype in colorectal cancer.

bioRxiv · Oct 20, 2023 · PreprintCancer Biology

T-cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy

A. S. Hansen, L. S. Jensen, K. G. Ryttersgaard, C. Krapp, J. Just, K. R. Gammelgaard, K. L. Jonsson, M. Johannsen, A. Etzerodt, B. W. Deleuran, M. R. Jakobsen

This study shows that T-cell derived extracellular vesicles enhance macrophage STING activation, improving cancer immunotherapy by reprogramming macrophages to a pro-inflammatory state.

bioRxiv · Jan 9, 2023Immunology

Distinct SARS-CoV-2 sensing pathways in pDCs driving TLR7-antiviral vs. TLR2-immunopathological responses in COVID-19

R. M. van der Sluis, L. B. Cham, A. G. Oliver, K. R. Gammelgaard, J. G. Pedersen, M. Idorn, U. Ahmodov, S. S. Hernandez, E. Cemalovic, S. H. Godsk, J. Thyrsted, J. D. Gunst, S. D. Nielsen, J. j. Jorgensen, T. W. Bjerg, , M. R. Jakobsen

The paper shows that pDCs use TLR7 for antiviral responses and TLR2 for inflammatory responses to SARS-CoV-2, with neuropilin-1 inhibiting antiviral IFNs.

bioRxiv · Nov 23, 2021 · PreprintImmunology