Author

T. Brocker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:flow cytometry· 2 Organism:human· 2 Assay:imaging· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

T. Straub· 4 shared J. Kranich· 3 shared L. Rausch· 3 shared A. B. Krug· 2 shared E. Winheim· 2 shared J. Hellmuth· 2 shared K. Lutz· 2 shared K. Stark· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

T. Straub

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Author profile →

6 papers

Recent·Most cited

Plasmacytoid dendritic cells regulate megakaryocyte and platelet homeostasis

F. Gaertner, H. Ishikawa-Ankerhold, S. Stutte, W. Fu, C. Guo, J. Weitz, A. Dueck, Z. Zhang, D. van den Heuvel, V. Fumagalli, M. Lorenz, L. von Baumgarten, K. Stark, T. Straub, S. von Stillfried, , S. Massberg

This study identifies plasmacytoid dendritic cells (pDCs) as regulators of megakaryopoiesis and platelet homeostasis, showing their role in maintaining steady-state and stress conditions, and their involvement in SARS-CoV2-induced thrombosis.

bioRxiv · May 31, 2022 · PreprintImmunology

Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patients

L. Rausch, K. Lutz, M. Schifferer, E. Winheim, R. Gruber, L. Rinke, J. Hellmuth, C. Scheerer, M. Muenchhoff, C. Mandel, M. Bergwelt-Baildon, M. Simons, T. Straub, A. B. Krug, J. Kranich, T. Brocker

The paper identifies PS+ PMPs as a marker for disease severity in COVID-19 by showing their correlation with immune dysfunction and clinical outcomes.

bioRxiv · Jun 18, 2021Immunology

Impaired function and delayed regeneration of dendritic cells in COVID-19

E. Winheim, L. Rinke, K. Lutz, A. Reischer, A. Leutbecher, L. Wolfram, L. Rausch, J. Kranich, P. R. Wratil, J. Huber, D. Baumjohann, S. Rothenfusser, J. Hellmuth, C. Scherer, M. Muenchhoff, , A. B. Krug

This study examines dendritic cell and monocyte function and regeneration in COVID-19 patients, finding persistent reductions and functional impairments linked to disease severity.

bioRxiv · May 26, 2021 · PreprintImmunology

Helicobacter hepaticus as disease driver in a novel CD40-mediated model of colitis

V. Friedrich, I. Forne, D. Matzek, D. Ring, B. Popper, L. Jochum, S. Spriewald, T. Straub, A. Imhof, A. Krug, B. Stecher, T. Brocker

This study identifies Helicobacter hepaticus as a disease driver in a CD40-mediated colitis model by showing its role in inducing inflammatory immune responses through specific antigen recognition.

bioRxiv · Apr 21, 2020 · PreprintImmunology

In vivo identification of apoptotic and extracellular vesicle-bound live cells using image-based deep learning

J. Kranich, N.-K. Chlis, L. Rausch, A. Latha, M. Schifferer, T. Kurz, A. Foltyn, M. Simons, F. J. Theis, T. Brocker

This paper introduces a method using fluorescent MFG-E8 and deep learning to identify apoptotic and EV-bound live cells in vivo, finding that most PS+ cells are live cells associated with EVs.

bioRxiv · Apr 14, 2020Cell Biology

Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8+ Dendritic Cells

M. Zwick, T. Ulas, Y.-L. Cho, C. Ried, L. Grosse, C. Simon, C. Bernhard, D. H. Busch, J. L. Schulze, V. Buchholz, S. Stutte, T. Brocker

This study shows that Ppef2 deficiency in CD8+ dendritic cells leads to increased apoptosis and reduced antigen presentation, impacting T cell responses.

bioRxiv · Jul 29, 2018Immunology