bioRxivBioinformaticsPreprint
TP53 Intron Derived Concentrations Implicate p53
Kevin Bermeister, Jonathan Dyne, Xinghao YuiD, Liran CarmeliD, Khens Kermesh, Adam Bermeister, Mark KoniD, Daniel Shnier
Abstract
Introduction Introduction Background Mechanisms of p53 Regulation... Relative Concentration Dynamics ... Method TP53 intronic half-sites... ID Gene-Transcript-Intron... Conclusion References TP53 is a highly studied gene due to its important regulatory role in DNA, RNA (Marcel, Catez, and Diaz 2015), disease and the progression of cancer. TP53 functions as a tumor suppressor and has been described as the \"Guardian of the Genome\". p53, the protein coded by TP53 predominantly binds regulatory response elements (\"RE\") in introns of multiple target genes. We compared identical subsequences in introns of multiple gene/transcripts including TP53, BRCA1, menl, PELP1, SET, HIF1A, ULBP1/2 and IRF3. Some identical subsequences also contain the ...
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