Max Trauernicht

Systematic comparison of estimates of transcription factor activity by ATAC-seq and multiplexed reporter assays

This study compares ATAC-seq-based estimates of transcription factor activity with multiplexed reporter assays across perturbations, finding overlap but also discrepancies in their sensitivity to different TF types.

Optimized reporters for multiplexed detection of transcription factor activity

The paper systematically optimizes transcriptional reporters for 86 transcription factors and identifies 60 highly sensitive and specific reporters.

Chromatin context-dependent effects of epigenetic drugs on CRISPR-Cas9 editing

This study identifies 67 epigenetic drugs that modulate CRISPR-Cas9 editing efficiency and repair outcomes based on chromatin context in human cells.

Optimisation of TP53 reporters by systematic dissection of synthetic TP53 response elements

The paper systematically examines how TP53 binding site architecture affects transcriptional output and develops a model to predict reporter activity.