Pelvic floor disorders treatments

Selective motor stimulation of the pudendal nerve using multi-contact cuff electrodes: a pre-clinical study in feline and ovine models

This study demonstrates that multi-contact cuff electrodes can selectively activate motor fibers of the pudendal nerve in feline and ovine models, improving selectivity for external urethral and anal sphincter responses.

Genome-wide association meta-analyses over one million individuals identify 54 loci associated with urinary incontinence and its subtypes

Macrophage-to-Myofibroblast Transition (MMT)- an adverse response to polypropylene mesh implanted for pelvic organ prolapse repair surgery in a non-human primate model

This study investigates how mesh deformation and tension affect macrophage-to-myofibroblast transition (MMT) and host response in a non-human primate model of pelvic organ prolapse repair.

Bioengineered visible polymeric mesh to enhance urogynaecological health

This paper introduces a bioengineered composite mesh for pelvic floor disorders, showing good biocompatibility and mechanical properties but requiring further refinement to reduce inflammation.

The use of autologous skeletal muscle-derived cells as a sling in the treatment of induced stress urinary incontinence, an experimental study

This study tests autologous skeletal muscle-derived cells seeded on PGA scaffolds as a treatment for stress urinary incontinence in dogs, showing increased urethral pressure and histological muscle proliferation.

Video-Based Deep Learning to Detect Dyssynergic Defecation with 3D High-Definition Anorectal Manometry

This paper develops a deep learning algorithm for 3D-HDAM to detect dyssynergia, showing comparable accuracy to traditional and hybrid models but better handling of ambiguous cases.

Advancing our understanding of genetic risk factors and potential personalized strategies in pelvic organ prolapse: largest GWAS to date reveals 19 novel associated loci

This paper identifies 19 novel genetic loci associated with pelvic organ prolapse through the largest GWAS to date and presents a polygenic risk score with predictive value for POP risk.