David M. Evans

The paper estimates heritability for behavioural and disease traits using 500,000 sibling pairs across diverse ancestries, finding substantial genetic contributions for smoking, alcohol use, personality, and diseases like T2D and asthma.

The paper conducts a multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycemic traits, identifying novel loci and highlighting limited pregnancy-specific genetic effects.

The paper tests associations between maternal KIR haplotypes and fetal HLA-C alleles with birth weight in a large sample, finding no significant interactions or replication of previous findings.

The paper identifies rDNA sequence variants associated with human traits using UK Biobank data, finding enrichment in body size traits within the 28S rRNA Expansion Segment 15L region.

This study identifies 33 genetic variants associated with trabecular bone score (TBS) and finds a potential causal link between TBS and fracture risk independent of bone mineral density.

This study uses Mendelian randomization to examine if fetal growth affects maternal cardiometabolic risk, finding no strong causal evidence.

This paper introduces an MR framework to estimate causal effects of offspring traits on parental health using parental genotypes as proxies for offspring genotypes.

The paper introduces a haplotype-based method to estimate maternal and fetal genetic contributions to pregnancy outcomes, finding that gestational duration is mainly influenced by maternal haplotypes while fetal size is influenced by both maternal and paternal haplotypes.

The paper investigates the interaction between FADS2 genotype and breastfeeding on various traits in the UK Biobank and finds no evidence of such an interaction.

DINGO improves locus discovery in GWAS of perinatal traits by combining maternal and fetal GWAS data through meta-analysis and novel statistical tests, identifying more genetic loci than separate analyses.

This study identifies 40 genetic loci associated with placental weight using GWAS in 179,025 children and parents, revealing shared and distinct genetic influences with fetal growth.

This study identifies genetic determinants of hip joint space width and finds they have opposing causal effects on hip osteoarthritis risk through distinct mechanisms.

This paper uses Mendelian randomization to investigate the causal relationship between maternal serum urate and offspring birthweight, finding a weaker causal effect compared to observational studies.

This paper uses structural equation modelling to partition the genetic effects of classical HLA alleles on birth weight into maternal and fetal components using UK Biobank data.

This paper uses structural equation modeling to partition maternal genetic effects into prenatal and postnatal components using adoption data from the UK Biobank.

The paper investigates a genotype by sex interaction in Ankylosing Spondylitis risk, showing it is driven by HLA-B rather than MICA variation.

The paper examines the effect of fetal genetic predispositions to metabolically favourable adult adiposity and BMI on birth weight and other anthropometric traits, finding stronger associations with birth weight for the adiposity alleles.

This study identifies 59 genome-wide significant loci for skull bone mineral density, including four novel loci, and links them to osteoporosis and craniofacial developmental defects.

This study uses Mendelian Randomisation to show that maternal metabolically favourable adiposity is associated with lower offspring birth weight compared to general adiposity indexed by BMI.

The paper compares multivariate methods to estimate direct and indirect genetic effects on offspring phenotypes using GWAS summary data, finding Genomic SEM most accurate and identifying novel fertility loci.

The paper maps the osteocyte transcriptome in mice, identifies 1239 genes, and links them to skeletal disease susceptibility in humans.

In 159,701 siblings from 17 cohorts, population GWAS overstate direct effects on height, education, smoking, cognition, depressive symptoms and age at first birth; clinical traits mostly agree across models.

The paper extends a method to estimate parent-specific genetic effects on offspring traits, applying it to UK Biobank data to analyze birthweight and BMI.

The paper introduces Trio-GCTA, a model to separate direct and indirect genetic effects in parent-offspring trios, applied to four phenotypes using real data.

This study uses Mendelian Randomization to assess the causal effect of maternal vitamin B12 and folate on offspring birthweight, finding a positive causal effect for folate but not for B12.

This paper estimates indirect parental genetic effects on offspring phenotypes using virtual parental genotypes derived from sibling and half-sibling pairs, demonstrating the feasibility of this approach with GWAS data.

This paper introduces within-family Mendelian randomization methods to reduce biases from family structure and shows they yield different results compared to population-based analyses.

The paper identifies SNPs with sex-specific effects on lung function traits using UK Biobank data, finding a significant interaction at rs7697189 near HHIP.

The paper identifies 9 novel genetic loci, including low-frequency variants in TP53, associated with head circumference and intracranial volume in up to 46,000 individuals.