Structural Mechanisms of DNAJC13 Dimeric Assembly and InsP6 binding in Recycling Endosome Regulation
Tao Fu, Chan Lee, Frances V Hundley, João A. Paulo, J. Wade Harper
Cryo-EM at 2.4 Å shows DNAJC13 as an antiparallel arch-shaped homodimer with a buried InsP6 pocket; dimerization controls WASH recruitment, tubule fission, and melanin production.
bioRxiv · Jul 29, 2026 · PreprintCell Biology✦ In-depth digest